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Hyperlipidemia in mast cell-deficient W/WV mice
Biochimica Et Biophysica Acta
|October 3, 1986
Summary
Mice lacking mast cells exhibit hyperlipidemia, with elevated triglycerides and cholesterol. This is linked to reduced plasma lipase activity, suggesting genetic defects in lipase secretion or function.
Area of Science:
- Biochemistry
- Genetics
- Physiology
Background:
- Mast cells play a role in lipid metabolism.
- Genetic defects can lead to metabolic disorders.
Purpose of the Study:
- To investigate the role of mast cells in lipid metabolism.
- To identify the underlying mechanisms of hyperlipidemia in W/WV mice.
Main Methods:
- Comparative analysis of lipid profiles in W/WV mice and congenic normal mice.
- Measurement of lipoprotein lipase and hepatic triacylglycerol lipase activities in plasma and tissues.
Main Results:
- W/WV mice showed hypertriglyceridemia and hypercholesterolemia (approx. 70%).
- Elevated levels of chylomicrons, VLDL, and IDL were observed in W/WV mice.
- Plasma lipase activities were significantly lower in W/WV mice post-heparin injection.
Conclusions:
- Genetic defects in W/WV mice impair lipase secretion, transport, or endothelial anchoring.
- Heparin deficiency may contribute to hyperlipidemia in these mice.
- Mast cell deficiency is associated with significant alterations in lipoprotein metabolism.