[Mathematical model of activation wave propagation in an isolated cardiomyocyte]
Related Experiment Video
Updated: Aug 14, 2026

Patient-specific Modeling of the Heart: Estimation of Ventricular Fiber Orientations
Published on: January 8, 2013
Abstract:
In order to describe spontaneous wave-like contractions of a single isolated cardiomyocyte a mathematical model is proposed, which relates this phenomenon to propagation of calcium ion concentration wave along the cell. Free diffusion of Ca2+ ions as well as their reversible binding to regulatory proteins in contractile apparatus, Ca2+ accumulation in sarcoplasmic reticulum, and Ca-induced Ca2+ release are included in the governing equations. The model agrees with some observations. It predicts also some effects which may by a subject of future experimental research.
Related Concept Videos
Generation of Action Potential in Skeletal Muscles
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the cell's...
Specialized Characteristics of Cardiac Muscles
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy reserves in...
Electrophysiology of Normal Cardiac Rhythm
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials

