Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetic Models: Overview01:20

Pharmacokinetic Models: Overview

786
Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal...
786
Three-Compartment Open Model01:06

Three-Compartment Open Model

273
The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
273
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

245
The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
245
Drug Delivery: Overview01:16

Drug Delivery: Overview

322
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
322

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of composition dependence in Flory-Huggins parameters on solid dispersion stability prediction.

International journal of pharmaceutics·2026
Same author

Efficacy of bumetanide for cognitive improvement in children and adolescents with Down syndrome: study protocol of a randomised, double-blind, placebo-controlled trial.

BMJ open·2026
Same author

Mathematical modelling of biofilm growth on medical implants incorporating nutrient-dependent phenotypic switching.

Mathematical medicine and biology : a journal of the IMA·2026
Same author

Use of lorazepam for analgosedation during mechanical ventilation in pediatric intensive care.

Frontiers in medicine·2026
Same author

Validation of an agent-based model for cell interactions in a microfluidic chip.

PloS one·2026
Same author

A general multi-stratum model for a nanofunctionalized releasing capsule: An experiment-driven computational study.

Mathematical biosciences and engineering : MBE·2026

Related Experiment Video

Updated: Jul 19, 2025

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.7K

Modelling smart drug release with functionally graded materials.

Gabriella Bretti1, Sean McGinty2, Giuseppe Pontrelli1

  • 1Istituto per le Applicazioni del Calcolo - CNR, Via dei Taurini 19 00185 Rome, Italy.

Computers in Biology and Medicine
|August 10, 2023
PubMed
Summary
This summary is machine-generated.

Functionally graded materials (FGMs) offer tunable drug release profiles. A mathematical model shows that varying drug diffusivity in FGMs enables diverse release patterns, unlike homogeneous materials.

Keywords:
Drug deliveryMathematical modelsNumerical methodsSmart materials

More Related Videos

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

10.8K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.9K

Related Experiment Videos

Last Updated: Jul 19, 2025

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate PolyLactic Acid Scaffolds with Graded Pore Size

Published on: October 17, 2016

8.7K
Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications
09:56

Fabrication of Mechanically Tunable and Bioactive Metal Scaffolds for Biomedical Applications

Published on: December 8, 2015

10.8K
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
09:11

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Published on: February 13, 2016

9.9K

Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Pharmacology

Background:

  • Functionally graded materials (FGMs) exhibit spatially varying properties, with applications in aerospace, automotive, and biomedical fields.
  • Despite their potential, FGMs are not fully utilized, particularly in advanced applications like controlled drug delivery.
  • Achieving tailored drug release profiles is crucial for effective therapeutic outcomes.

Purpose of the Study:

  • To explore the potential of FGMs in drug delivery applications.
  • To develop a mathematical model for predicting drug release from thin-film FGMs.
  • To investigate how spatially varying drug diffusivity influences drug release kinetics.

Main Methods:

  • Development of a mathematical model simulating drug release from a thin film FGM.
  • Incorporation of a spatially-varying drug diffusivity within the FGM model.
  • Analysis of drug release profiles based on different functional forms of diffusivity.

Main Results:

  • Demonstrated that FGMs can achieve a wide range of drug release profiles.
  • Showed that the release profile shape is dependent on the functional form of the spatially varying drug diffusivity.
  • Highlighted that these diverse release profiles are generally not attainable with homogeneous materials exhibiting constant diffusivity.

Conclusions:

  • Functionally graded materials offer a promising platform for fine-tuning drug release kinetics.
  • The mathematical model provides a framework for designing FGMs with specific drug release characteristics.
  • FGMs enable drug delivery profiles unattainable with conventional homogeneous materials.