Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
Instrument Calibration01:12

Instrument Calibration

219
Instrument calibration is essential for ensuring that instruments produce accurate and consistent results. It is vital in manufacturing, healthcare, testing laboratories, and scientific research. Calibration processes are specific to each instrument and help enhance data accuracy. Each instrument has a unique calibration process tailored to its design and function to improve data accuracy.
Analytical Balance Calibration
An analytical balance measures mass and requires regular calibration to...
219

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diagnostic utility of hematological and biochemical markers for cystic echinococcosis in Tibetan patients of Sichuan, China.

Frontiers in cellular and infection microbiology·2025
Same author

Automatic kidney stone identification: an adaptive feature-weighted LSTM model based on urine and blood routine analysis.

Urolithiasis·2024
Same author

Correlation analysis of peripheral platelet markers and disease phenotypes in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2024
Same author

Design, synthesis and biological evaluation of 3-aryl-7-hydroxy scopoletin derivatives as autophagy activators against tumorigenesis.

European journal of medicinal chemistry·2022
Same author

Isolation of circulating exosomes and identification of exosomal PD-L1 for predicting immunotherapy response.

Nanoscale·2022
Same author

Effects of Lactobacillus fermentum HY01 on the quality characteristics and storage stability of yak yogurt.

Journal of dairy science·2022
Same journal

Micro- and nanoplastics as emerging clinical analytes: analytical validation, interpretive uncertainty, and laboratory actionability in human specimens.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Performance of Free Light Chain reagents in the Dutch External Quality Assessment programme over the past 14 years.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

CRISPR-Cas12a-based liquid biopsy technology: challenges in large-scale clinical application.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Diagnostic biomarkers, prognostic signatures, and therapeutic resistance: shedding light on the dual role of autophagy in glioblastoma.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Artificial intelligence in diagnostic software: validation, safety, and lifecycle challenges in Europe.

Clinica chimica acta; international journal of clinical chemistry·2026
Same journal

Strategies for effective occurrence Management in Resource-Limited Clinical Laboratories: Challenges and practical solutions.

Clinica chimica acta; international journal of clinical chemistry·2026
See all related articles

Related Experiment Video

Updated: Jul 19, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K

A mathematical algorithm to harmonize measurements for thyroid-stimulating hormone between instruments.

Xin Zhou1, Zaishuan Liu2, Yining Ma3

  • 1Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China; Jintang First People's Hospital, Chengdu 610400, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|August 10, 2023
PubMed
Summary
This summary is machine-generated.

A new mathematical algorithm harmonizes thyroid-stimulating hormone (TSH) measurements between different laboratory instruments. This TSH harmonization method significantly reduces measurement errors, improving data comparability across diagnostic units.

Keywords:
ComparabilityConversionDeterminationMathematical algorithmThyroid-stimulating hormone (TSH)

More Related Videos

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

433
Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays
12:48

Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays

Published on: February 19, 2013

10.6K

Related Experiment Videos

Last Updated: Jul 19, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

1.7K
Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

433
Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays
12:48

Measuring Cation Transport by Na,K- and H,K-ATPase in Xenopus Oocytes by Atomic Absorption Spectrophotometry: An Alternative to Radioisotope Assays

Published on: February 19, 2013

10.6K

Area of Science:

  • Clinical chemistry
  • Biomedical engineering
  • Medical laboratory science

Background:

  • Thyroid-stimulating hormone (TSH) measurements vary significantly between different diagnostic instruments.
  • This variability poses challenges for accurate cross-comparison of TSH data.
  • Harmonization of TSH assays is crucial for reliable clinical interpretation.

Purpose of the Study:

  • To develop and validate a mathematical algorithm for harmonizing TSH measurements.
  • To improve the comparability of TSH data obtained from different laboratory instruments.
  • To reduce inter-instrument variability in TSH quantification.

Main Methods:

  • Calculated the minimum required comparison samples for TSH detection on Abbott ISR2000 and Siemens ADVIA Centaur XP.
  • Developed a mathematical algorithm to describe the relationship between TSH standard curves of the two instruments.
  • Transformed TSH signals to Siemens ADVIA Centaur XP data and assessed relative error against total allowable error (TEa).

Main Results:

  • Before harmonization, the mean percentage error in TSH measurements between instruments was 23.20% (>1/2 TEa).
  • After applying the algorithm, the average percentage error was reduced to 7.93% (<1/2 TEa).
  • The developed algorithm effectively reduced TSH measurement discrepancies.

Conclusions:

  • The mathematical algorithm successfully harmonizes TSH measurements between the Abbott ISR2000 and Siemens ADVIA Centaur XP.
  • This method enables comparable TSH data across different laboratory instruments.
  • Provides a valuable tool for harmonizing TSH data in multi-laboratory settings.