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Chronic pain after hospital discharge on patients hospitalized for COVID-19: an observational study
Guilherme Antonio Moreira de Barros1, Douglas Inomata Cardoso da Silva1, Mariana Lopes Amaral Barbosa1
1Universidade Estadual Paulista (Unesp), Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, Botucatu, SP, Brazil.
Insights
Chronic pain is common after hospitalization for Coronavirus Disease 2019 (COVID-19). Female sex and obesity are significant risk factors for developing persistent pain following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Area of Science:
- Medical Research
- Infectious Diseases
- Pain Management
Background:
- Limited research exists on post-discharge pain symptoms in Coronavirus Disease 2019 (COVID-19) survivors, particularly those with moderate to severe illness.
- Understanding the prevalence and characteristics of chronic pain after COVID-19 hospitalization is crucial for patient recovery and long-term health management.
Purpose of the Study:
- To investigate the occurrence of chronic pain in patients hospitalized for COVID-19.
- To explore the relationship between chronic pain and factors such as intensive care unit (ICU) stay, demographics, and risk factors for severe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection.
Main Methods:
- A cross-sectional observational study was conducted with 242 patients at least 3 months post-discharge.
- Data collected included demographics, infection severity (including ICU stay), and presence of chronic pain.
- Multivariate analysis was used to determine Odds Ratios (ORs) and Confidence Intervals (CIs) for associated risk factors.
Main Results:
- Approximately 31.8% (77 out of 242) of COVID-19 survivors reported chronic pain.
- Chronic pain was not correlated with infection severity or ICU stay.
- Female sex (OR 2.69) and obesity (OR 3.02) were significantly associated with a higher risk of developing chronic pain, with limbs being the most affected areas.
Conclusions:
- Chronic pain is a prevalent condition among individuals hospitalized for COVID-19.
- Identifying female sex and obesity as key risk factors can aid in targeted screening and management strategies for post-COVID-19 pain.
Background:
There are few studies related to Coronavirus Disease 2019 (COVID-19) on the prevalence and nature of pain symptoms after hospital discharge, especially in individuals who develop moderate to severe disease forms. Therefore, this study aimed to evaluate the presence of chronic pain in patients discharged after hospitalization for COVID-19, and the relationship between the presence of chronic pain and intensive care stay, demographics, and risk factors for the worst Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outcome.
Methods:
A cross-sectional observational study was carried out on patients with COVID-19 who recovered after hospitalization. Patients were recruited at the least 3 months after discharge and their hospital's health files were prospected. The variables evaluated were demographics, the severity of SARS-CoV-2 infection (considering the need for intensive care), and the presence of chronic pain. The results were shown in a descriptive manner, and multivariate analysis expressed as Odds Ratios (ORs) and respective Confidence Intervals (CIs) for the outcomes studied. Statistical significance was set at p < 0.05.
Results:
Of 242 individuals included, 77 (31.8%) reported chronic pain related to COVID-19, with no correlation with the severity of infection. Female sex and obesity were associated with a higher risk for chronic pain with ORs of 2.69 (Confidence Interval [95% CI 1.4 to 5.0]) and 3.02 (95% CI 1.5 to 5.9). The limbs were the most affected areas of the body.
Conclusion:
Chronic pain is common among COVID-19 survivors treated in hospital environments. Female sex and obesity are risk factors for its occurrence.
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