Related Experiment Video

Updated: Jul 19, 2025

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

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Next-generation antibody-drug conjugates for breast cancer: Moving beyond HER2 and TROP2

Ilana Schlam1, Ruth Moges2, Stefania Morganti3

  • 1Department of Hematology and Oncology, Tufts Medical Center, Boston, MA, USA.

Critical Reviews in Oncology/Hematology
|August 10, 2023
PubMed

Insights

Antibody-drug conjugates (ADCs) are revolutionizing cancer therapy, particularly for breast cancer. Ongoing research explores novel ADCs with innovative designs and targets to improve efficacy and reduce toxicity for better patient outcomes.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • Antibody-drug conjugates (ADCs) have significantly advanced cancer treatment, with approved agents for breast cancer subtypes targeting HER2 and TROP2.
  • The efficacy and safety of ADCs are determined by their antibody, linker, and payload components, which can be modified to alter clinical profiles.

Purpose of the Study:

  • To review the evolving landscape of novel antibody-drug conjugates (ADCs) in cancer therapy.
  • To highlight emerging opportunities and challenges in the development of next-generation ADCs.

Main Methods:

  • Literature review of current and investigational antibody-drug conjugates.
  • Analysis of ADC components and novel construct designs.

Main Results:

  • Established ADCs targeting HER2 and TROP2 have transformed breast cancer treatment.
  • Numerous novel ADC strategies are under investigation, including targeting new antigens and employing innovative designs like bispecific ADCs, dual payloads, and immune-modulating constructs.

Conclusions:

  • The field of ADCs is rapidly advancing, offering promising new therapeutic avenues for various malignancies.
  • Continued innovation in ADC design and targeting holds significant potential for improving cancer treatment outcomes.
Keywords:
Antibody-drug conjugatesBreast cancerDrug developmentTargeted therapies

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