Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rates and predictors of intraventricular hemorrhage in the ventfirst trial with comparison to a contemporaneous cohort.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

MRI in Sheep Model for Myelomeningocele Repair Using a Novel Polymer and Other Dural Patches.

Prenatal diagnosis·2026
Same author

Feasibility of Non-Sedated Multispectral Neuroimaging in Newly Diagnosed Children with Leukemia.

medRxiv : the preprint server for health sciences·2026
Same author

Temporal trends in outcomes for infants with neonatal opioid withdrawal managed with the Finnegan scoring tool: Insights from the INFORM NOW Study.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Neonatal brain abnormalities predict preschool executive functioning performance in children born very preterm.

Developmental psychology·2026
Same author

Association between medication for opioid use disorder during pregnancy and neonatal outcomes.

Journal of perinatology : official journal of the California Perinatal Association·2025

Related Experiment Video

Updated: Jun 9, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.3K

DTI of Opioid-Exposed Fetuses Using ComBat Harmonization: A Bi-Institutional Study.

J A Dudley1,2, U D Nagaraj3,2, S Merhar2,4

  • 1From the Department of Radiology and Medical Imaging (J.A.D., U.D.N., B.M.K.-F., W.Y.), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

AJNR. American Journal of Neuroradiology
|August 10, 2023
PubMed
Summary
This summary is machine-generated.

Prenatal opioid exposure may alter fetal brain white matter (WM) development. Diffusion tensor imaging (DTI) revealed significant differences in WM microstructure in opioid-exposed fetuses compared to controls.

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.5K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.5K

Related Experiment Videos

Last Updated: Jun 9, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.3K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.5K
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

8.5K

Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Prenatal Health

Background:

  • Mechanisms behind cognitive, behavioral, and vision deficits in children exposed to opioids prenatally remain unclear.
  • Existing research suggests white matter (WM) alterations in infants and children with prenatal opioid exposure, but the timeline of these changes is unknown.

Purpose of the Study:

  • To investigate differences in brain diffusion tensor imaging (DTI) MRI parameters between fetuses exposed to opioids and healthy controls.
  • To evaluate potential early microstructural changes in the fetal brain due to prenatal opioid exposure.

Main Methods:

  • A pilot, prospective cohort study involving third-trimester pregnant subjects.
  • Fetal DTI of the brain was performed using 20 noncolinear diffusion directions and a b-value of 500 s/mm² at 2.5-mm isotropic resolution.

Main Results:

  • The study included 26 fetuses (11 opioid-exposed, 15 controls).
  • After adjusting for gestational age, opioid-exposed fetuses showed significantly higher fractional anisotropy values in 8 specific WM tracts compared to controls.
  • Additional DTI indices indicated significant alterations in various brain regions.

Conclusions:

  • The findings provide preliminary evidence of cerebral WM microstructural differences in fetuses exposed to opioids.
  • Larger population studies are necessary to fully elucidate these microstructural changes and their long-term implications.