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Membrane traffic governs the STING inflammatory signalling.

Tomohiko Taguchi1

  • 1Laboratory of Organelle Pathophysiology, Department of Integrative Life Sciences, Graduate School of Life Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai, Miyagi 980-8578, Japan.

Journal of Biochemistry
|August 10, 2023
PubMed
Summary

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway drives inflammation. STING protein movement from the ER to other organelles is key for its signaling and immune response.

Keywords:
STINGinnate immunitymembrane trafficmicroautophagypalmitoylation

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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • The cGAS-STING pathway is a key innate immune sensor for cytosolic double-stranded DNA (dsDNA).
  • This pathway triggers type I interferon production via IRF3 activation, crucial in antiviral responses, stress, and tissue damage.
  • Dysregulation of this pathway is implicated in autoinflammatory diseases.

Conclusions:

  • Understanding STING's dynamic membrane trafficking is critical for its function in innate immunity.
  • Targeting STING trafficking offers potential therapeutic strategies for chronic inflammation and cancer.
  • Further research into STING-associated diseases may reveal new treatment avenues.