Related Experiment Video
Updated: Jul 19, 2025
08:41
Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
Published on: August 14, 2021
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Neuromuscular pathology
Anthony A Amato1, Umberto De Girolami2
1Department of Neurology, Division of Neuromuscular Diseases, Neuropathology Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Handbook of Clinical Neurology
|August 10, 2023
Summary
This chapter covers muscle, nerve, and skin biopsies, including their indications, processing, and normal histology. It details common histopathological abnormalities in myopathies and neuropathies for accurate diagnosis.
Area of Science:
- Neurology
- Histopathology
- Biopsy techniques
Background:
- Muscle, nerve, and skin biopsies are crucial diagnostic tools in neurology.
- Understanding normal histological findings is essential for identifying abnormalities.
- Myopathies and neuropathies present diverse histopathological features.
Approach:
- Discusses indications for performing muscle, nerve, and skin biopsies.
- Details techniques for specimen collection and normal processing.
- Explains normal histological appearance and common abnormalities.
Key Points:
- Biopsy indications and specimen processing are outlined.
- Normal histological features of muscle, nerve, and skin are described.
- Common histopathological abnormalities in myopathies and neuropathies are reviewed.
Conclusions:
- This chapter provides a comprehensive overview of biopsy interpretation in neuromuscular disorders.
- It serves as a guide for understanding histopathological findings in myopathies and neuropathies.
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