Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

162
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
162
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

201
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
201
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

263
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
263
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

365
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
365
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

268
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
268

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resource-efficient retrieval-augmented question answering for the Indian Lok Sabha dataset.

Frontiers in artificial intelligence·2026
Same author

Distribution of Non-Tuberculous Mycobacterium Species in Pulmonary and Extrapulmonary Infections in South India-A Retrospective Analysis.

Microorganisms·2026
Same author

Visions at Life's End: Normalising and Validating Distressing End-of-Life Experiences - A Case Report.

Indian journal of palliative care·2026
Same author

N-acetylcysteine: evidence based consensus document on the therapeutic advantages in respiratory diseases (NECTAR).

Frontiers in medicine·2026
Same author

Diagnostic accuracy and safety of Cy-Tb for detection of tuberculosis infection: A multicentric study from India.

The Indian journal of medical research·2026
Same author

Intranetwork variation in neoadjuvant therapy delivery for borderline resectable and locally advanced pancreatic cancer: a UK multicentre cohort study.

Annals of the Royal College of Surgeons of England·2026
Same journal

Ethical challenges in community-based tuberculosis screening and surveillance.

The Indian journal of tuberculosis·2026
Same journal

Effectiveness of e-learning modules in community-based tuberculosis awareness programs.

The Indian journal of tuberculosis·2026
Same journal

Role of digital media campaigns in improving TB health literacy at the community level.

The Indian journal of tuberculosis·2026
Same journal

Digital case-based learning for improving clinical decision-making in tuberculosis care.

The Indian journal of tuberculosis·2026
Same journal

Simulation and virtual reality applications in medical training for tuberculosis diagnosis.

The Indian journal of tuberculosis·2026
Same journal

Use of tele-education for strengthening community participation in tuberculosis control.

The Indian journal of tuberculosis·2026
See all related articles

Related Experiment Video

Updated: Jul 19, 2025

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
09:54

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Published on: February 16, 2020

5.8K

Newer TB diagnostics: An update.

Priya Rajendran1, C Padmapriyadarsini1, Sanjeev Nair2

  • 1ICMR-National Institute for Research in Tuberculosis, Chetpet, Chennai, India.

The Indian Journal of Tuberculosis
|August 10, 2023
PubMed
Summary
This summary is machine-generated.

Nucleic-acid amplification tests (NAATs) have advanced tuberculosis diagnostics. Whole genome sequencing (WGS) offers comprehensive drug resistance prediction for more accurate clinical decisions.

Keywords:
Drug-resistant tuberculosisNAATsPoint of care testsSequencingTuberculosis

More Related Videos

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
08:10

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

80.8K
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.1K

Related Experiment Videos

Last Updated: Jul 19, 2025

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
09:54

Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection

Published on: February 16, 2020

5.8K
Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test
08:10

Diagnosing Pulmonary Tuberculosis with the Xpert MTB/RIF Test

Published on: April 9, 2012

80.8K
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.1K

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Molecular Diagnostics

Background:

  • Nucleic-acid amplification tests (NAATs) have significantly improved tuberculosis (TB) diagnostics.
  • Current point-of-care (POC) NAATs include Xpert MTB/RIF and Truenat, with future tests like Xpert Omni and Xpert MTB/XDR anticipated.
  • Line probe assays are utilized in reference laboratories for detecting Mycobacterium tuberculosis (MTB) and its drug resistance.

Purpose of the Study:

  • To review the current landscape of NAATs for TB diagnostics.
  • To highlight the role of Whole Genome Sequencing (WGS) in predicting drug resistance.
  • To emphasize the impact of advanced diagnostics on clinical decision-making for TB treatment.

Main Methods:

  • Review of WHO 2021 Guidelines on Diagnostics.
  • Description of currently used and emerging POC NAATs.
  • Explanation of line probe assay and Whole Genome Sequencing (WGS) applications in TB drug resistance detection.

Main Results:

  • NAATs are highly specific and sensitive tools transforming TB diagnosis.
  • Xpert MTB/RIF and Truenat are established POC NAATs; Xpert Omni and MTB/XDR are upcoming.
  • Whole genome sequencing (WGS) provides comprehensive drug resistance prediction by analyzing multiple gene regions or the entire genome.

Conclusions:

  • NAATs have revolutionized TB diagnostics, offering sensitive and specific detection.
  • Whole genome sequencing (WGS) presents a powerful platform for accurate and comprehensive prediction of drug resistance in MTB.
  • Advanced molecular diagnostic tools enable precise clinical decisions for effective TB management.