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Association between coffee and incident heart failure: A prospective cohort study from the UK Biobank

Qiang Han1, Jiadong Chu1, Wei Hu1

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China.

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
|August 10, 2023
PubMed

Insights

Moderate coffee consumption may lower heart failure risk. However, very high intake might increase risk, though this effect may not be significant in certain groups.

Area of Science:

  • Cardiovascular epidemiology
  • Nutritional science
  • Public health

Background:

  • The association between coffee intake and heart failure (HF) incidence remains unclear.
  • Existing research has not fully addressed time-varying coffee consumption patterns.
  • This study investigates the link between dynamic coffee consumption and new-onset HF.

Purpose of the Study:

  • To examine the relationship between time-varying coffee consumption and incident heart failure.
  • To clarify the dose-response association between coffee intake and HF risk.
  • To explore potential modifying effects of factors like gender and smoking.

Main Methods:

  • Utilized UK Biobank data from 497,503 adults, HF-free at baseline.
  • Employed marginal structural models (MSM) to handle time-varying confounders and loss to follow-up.
  • Applied restricted cubic splines to assess nonlinear relationships between coffee consumption and HF risk.

Main Results:

  • A J-shaped, nonlinear association was observed between coffee consumption and HF risk (P < 0.001).
  • Consuming 1-4 cups of coffee daily was linked to a reduced HF risk compared to less than 1 cup.
  • >6 cups/day was associated with increased HF risk, but this was not significant in sensitivity analyses by gender or smoking status.
  • Coffee type significantly influenced HF incidence (P < 0.05).

Conclusions:

  • Moderate coffee consumption (1-4 cups/day) may be associated with a lower risk of heart failure incidence.
  • High coffee consumption (>6 cups/day) may not significantly increase HF risk in certain subgroups.
  • Coffee type is a significant factor in HF incidence.
Abstract

Keywords:
CoffeeHeart failureIncidenceMarginal structural models

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