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Valvular heart disease and cardiomyopathy: reappraisal of their interplay

Nina Ajmone Marsan1, Francesca Graziani2, Maria Chiara Meucci3,2

  • 1Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands. n.ajmone@lumc.nl.

Nature Reviews. Cardiology
|August 10, 2023
PubMed

Insights

Cardiomyopathies and valvular heart diseases often coexist due to shared causes and affect prognosis. Understanding their interplay is key for improved risk stratification and personalized treatment strategies.

Area of Science:

  • Cardiology
  • Translational Medicine

Background:

  • Cardiomyopathies and valvular heart diseases are traditionally viewed as separate entities.
  • Increasing evidence highlights their frequent coexistence and shared etiological factors.
  • Conditions like dilated and hypertrophic cardiomyopathy often present with mitral regurgitation.

Purpose of the Study:

  • To review the scenarios where valvular heart diseases and cardiomyopathies coexist.
  • To emphasize the need for a better understanding of their shared pathophysiology.
  • To explore implications for disease classification, risk stratification, and personalized therapy.

Main Methods:

  • Literature review of studies on the association between cardiomyopathies and valvular heart diseases.
  • Analysis of shared etiological factors (genetic and acquired).
  • Discussion of prognostic and therapeutic implications of their coexistence.

Main Results:

  • Shared etiologies between cardiomyopathies and valvular heart diseases are common.
  • The association significantly impacts patient prognosis and treatment decisions.
  • Current classifications may not adequately address the combined impact of these conditions.

Conclusions:

  • An improved classification and clustering of these coexisting diseases is necessary.
  • Understanding shared mechanisms can lead to better risk assessment.
  • Personalized therapeutic approaches are crucial for managing combined cardiomyopathies and valvular heart diseases.

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