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Association between systemic immune-inflammation index and chronic obstructive pulmonary disease: a population-based
Chenglin Ye1, Li Yuan2, Kailang Wu3
1Department of Clinical Laboratory, institute of translational medicine, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, PR China.
BMC Pulmonary Medicine
|August 10, 2023
Summary
Higher Systemic Immune-Inflammation Index (SII) levels are associated with increased chronic obstructive pulmonary disease (COPD) prevalence and higher mortality risk in COPD patients. Further research is needed to confirm these findings.
Area of Science:
- Pulmonology
- Immunology
- Epidemiology
Background:
- The Systemic Immune-Inflammation Index (SII) quantifies the body's immune-inflammatory response.
- Previous studies highlight SII's prognostic value in critical illness, sepsis, and cancer.
- The association between SII and chronic obstructive pulmonary disease (COPD) requires further investigation.
Purpose of the Study:
- To investigate the correlation between SII and COPD prevalence.
- To examine the relationship between SII and all-cause mortality in COPD patients.
Main Methods:
- Analysis of demographic data from 16,636 National Health and Nutrition Examination Survey participants.
- Logistic regression and Cox proportional hazards models were used to assess SII's association with COPD and mortality.
- Propensity score matching (PSM) was employed to control for baseline differences between COPD and healthy populations.
Main Results:
- Higher SII levels were independently associated with an increased likelihood of COPD (OR=1.449, P<0.0001).
- Significant positive correlations between SII and COPD were observed across various subgroups.
- Increased SII was linked to higher all-cause mortality rates in the general population (HR=1.161), COPD patients (HR=1.282), and healthy individuals (HR=1.129).
Conclusions:
- Elevated SII levels are linked to a higher prevalence of COPD.
- COPD patients with higher SII levels face an increased risk of all-cause mortality.
- Large-scale, long-term studies are recommended to validate these findings.
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