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Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis

Yuqing Ren1,2, Ruizhi Wang1, Siyuan Weng1

  • 1Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.

Molecular Cancer
|August 10, 2023
PubMed

Insights

Disruptions in redox homeostasis, involving reactive oxygen species (ROS), are linked to cancer. This study explores how ROS impacts apoptosis, autophagy, and anti-tumor immunity within the tumor microenvironment.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Immunology

Background:

  • Redox homeostasis is a critical signaling pathway influencing physiological responses.
  • Imbalances in redox homeostasis, particularly reactive oxygen species (ROS) levels, are implicated in cancer development and progression.
  • The tumor microenvironment (TME) involves complex interactions between immunity, cell death (apoptosis, autophagy), and ROS.

Purpose of the Study:

  • To investigate the mechanisms by which multi-source ROS influences apoptosis, autophagy, and anti-tumor immunity in the TME.
  • To elucidate the crosstalk between ROS, apoptosis, autophagy, and anti-tumor immune responses.
  • To examine the relationship between conventional cancer therapies and ROS, and explore potential ROS-targeted treatments.

Main Methods:

  • The study will analyze the role of ROS in regulating apoptosis and autophagy within the TME.
  • Investigate the impact of ROS on anti-tumor immune responses.
  • Examine the interplay between ROS, cell death pathways, and immune evasion in cancer.

Main Results:

  • ROS levels and species significantly affect cell fate, immune capacity, and regulatory cell death (apoptosis and autophagy) in the TME.
  • A complex crosstalk exists between ROS, apoptosis, autophagy, and anti-tumor immunity.
  • ROS plays a crucial role in modulating the efficacy of traditional cancer therapies.

Conclusions:

  • Understanding ROS-mediated regulation of apoptosis, autophagy, and immunity in the TME is vital for cancer therapy.
  • ROS-targeted strategies hold promise for novel cancer treatment approaches.
  • Further research into the intricate role of ROS in cancer is warranted.
Keywords:
ApoptosisAutophagyCancer therapyImmunityRedox and ROS

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