Related Experiment Video
Updated: Jul 19, 2025

09:39
Preparation of Peripheral Nerve Stimulation Electrodes for Chronic Implantation in Rats
Published on: July 14, 2020
7.9K
Intractable hiccups after VNS implantation: a case report
Susan Zhang Recio1, Myriam Abdennadher2
1Department of Neurology, Boston Medical Center/Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.
BMC Neurology
|August 10, 2023
Summary
Vagus nerve stimulator (VNS) implantation, used for epilepsy, can paradoxically cause intractable hiccups (singultus). This case report highlights the need for awareness of this rare adverse effect, as hiccups resolved only after VNS deactivation.
Area of Science:
- Neurology
- Neurosurgery
Background:
- Intractable hiccups (singultus) severely impact quality of life, causing malnutrition and depression.
- Vagus nerve stimulator (VNS) implantation is typically used to treat intractable hiccups.
- This report details a case where VNS implantation for epilepsy led to intractable hiccups.

