Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

336
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
336
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

2.9K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Kang et al. Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers. <i>Polymers</i> 2020, <i>12</i>, 2421.

Polymers·2026
Same author

Correction: Platelet-membrane-biomimetic nanoparticles for targeted antitumor drug delivery.

Journal of nanobiotechnology·2026
Same author

High-throughput identification of bacterial β-glucuronidase inhibitors using machine learning.

Gut microbes·2026
Same author

Correction: Functionalized boron nanosheets as an intelligent nanoplatform for synergistic low-temperature photothermal therapy and chemotherapy.

Nanoscale·2026
Same author

Corrigendum to "Dual-responsive drug delivery systems prepared by blend electrospinning" [Int. J. Pharm. 543(1-2) (2018) 1-7].

International journal of pharmaceutics·2026
Same author

Corrigendum to "Thermosensitive nanofibers loaded with ciprofloxacin as antibacterial wound dressing material" [Int. J. Pharm. 517(1-2) (2017) 135-147].

International journal of pharmaceutics·2026

Related Experiment Video

Updated: Jul 19, 2025

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
09:27

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues

Published on: February 17, 2017

10.4K

Polymorphic transitions in flufenamic acid-trehalose composites.

Yuying Pang1, Simon Gaisford1, Oxana V Magdysyuk2

  • 1UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, United Kingdom.

International Journal of Pharmaceutics: X
|August 11, 2023
PubMed
Summary
This summary is machine-generated.

Amorphous solid dispersions (ASDs) improve drug solubility but can be unstable. This study shows that controlling trehalose content in flufenamic acid (FFA) ASDs influences crystallization pathways and drug forms, enhancing stability.

Keywords:
Differential Scanning CalorimetryFlufenamic acidSolid DispersionsSynchrotron X-ray diffractionTrehalose

More Related Videos

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

7.9K
Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
10:54

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Published on: June 19, 2015

9.8K

Related Experiment Videos

Last Updated: Jul 19, 2025

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
09:27

Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues

Published on: February 17, 2017

10.4K
Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
06:55

Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

Published on: September 26, 2016

7.9K
Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization
10:54

Facile and Efficient Preparation of Tri-component Fluorescent Glycopolymers via RAFT-controlled Polymerization

Published on: June 19, 2015

9.8K

Area of Science:

  • Pharmaceutical Science
  • Materials Science
  • Solid-State Chemistry

Background:

  • Amorphous solid dispersions (ASDs) enhance the solubility and bioavailability of poorly soluble drugs.
  • However, ASDs often exhibit poor physical stability, leading to recrystallization.

Purpose of the Study:

  • To investigate the crystallization behavior of flufenamic acid (FFA) in ASDs formulated with trehalose.
  • To determine if formulation composition can control the polymorphic form of FFA upon crystallization.

Main Methods:

  • Preparation of FFA-trehalose ASDs at various weight ratios.
  • Monitoring of phase transitions using simultaneous differential scanning calorimetry (DSC) and X-ray diffraction (XRD).
  • Analysis of drug crystallization upon storage and heating/cooling cycles.

Main Results:

  • FFA-trehalose ASDs exhibited composition-dependent crystallization pathways.
  • Low trehalose content (5:1 FFA:trehalose) resulted in Form I FFA upon storage, while higher trehalose content yielded Form IV.
  • All compositions recrystallized to Form I upon heating, but subsequent cooling produced Form IV (low trehalose) or Form I (high trehalose).

Conclusions:

  • The crystallization pathway and resulting polymorphic form of flufenamic acid from ASDs can be controlled by adjusting the trehalose content.
  • Judicious selection of formulation parameters, even with a single excipient, is crucial for achieving stable amorphous solid dispersions.