Related Experiment Video

Updated: Jul 19, 2025

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

3.6K

Blood pressure control and left ventricular echocardiographic progression in hypertensive patients: an 18-month

Yan Yang1, Yan Li1, Limin Zhu1

  • 1Department of Cardiovascular Medicine, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Cardiovascular Medicine
|August 11, 2023
PubMed

Insights

Effective blood pressure (BP) control is crucial for preventing cardiac changes in hypertension. Global longitudinal strain (GLS) changes indicate worsening heart function earlier than traditional measures, highlighting the importance of timely BP management.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • The impact of blood pressure (BP) control timing on left ventricular (LV) structure and function in essential hypertension is not fully understood.
  • Early detection of cardiac changes in hypertensive patients is vital for timely intervention.

Purpose of the Study:

  • To evaluate the correlation between BP control and conventional LV geometry/function indexes versus global longitudinal strain (GLS) progression.
  • To determine the timing of echocardiographic changes in essential hypertension relative to BP control.

Main Methods:

  • A longitudinal study of 62 uncontrolled hypertensive patients followed for 18 months with regular echocardiographic measurements and BP evaluation.
  • Patients were categorized into BP-controlled and uncontrolled groups at 6- and 18-month follow-ups.
  • Analysis included LV mass index, relative wall thickness, E/e', and GLS, with regression analysis to identify associations.

Main Results:

  • At 6 months, uncontrolled BP was associated with higher LV mass index, left atrial volume index, and worse GLS compared to controlled BP.
  • At 18 months, uncontrolled BP showed higher LV mass index, increased relative wall thickness, higher E/e', and worse GLS.
  • GLS changes significantly correlated with BP control at both 6 and 18 months; LV mass index changes correlated with systolic BP at 18 months.

Conclusions:

  • BP control significantly impacts LV structure and function, with GLS changes appearing earlier and more subtly than conventional echocardiographic parameters.
  • Significant GLS changes were observed as early as 6 months in patients with uncontrolled BP.
  • These findings underscore the clinical importance of achieving timely BP control to mitigate cardiac remodeling and dysfunction in hypertensive individuals.
Abstract

Keywords:
blood pressure controlechocardiographyglobal longitudinal strainhypertensionleft ventricular mass index

More Related Videos

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

146
Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients08:37

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

353

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
27
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
15
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
11
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
16
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
14