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The PH-ILD Detection tool: External validation and use in patients with ILD.
Raj Parikh1, David M O'Sullivan2, Harrison W Farber3
1Division of Pulmonary, Critical Care and Sleep, Hartford Hospital Hartford Connecticut USA.
Pulmonary Circulation
|August 11, 2023
Summary
The PH-ILD Detection tool accurately identifies pulmonary hypertension (PH) in interstitial lung disease (ILD) patients. This validated tool aids early diagnosis, improving patient management and treatment strategies for PH-ILD.
Area of Science:
- Pulmonology
- Cardiology
- Medical Diagnostics
Background:
- Pulmonary hypertension (PH) significantly increases morbidity and mortality in patients with interstitial lung disease (ILD).
- Early detection of PH in ILD patients is crucial for timely intervention, treatment initiation, and lung transplant evaluation.
Purpose of the Study:
- To validate the previously developed PH-ILD Detection tool in an independent, multicenter cohort of ILD patients.
- To assess the tool's efficacy in identifying patients with PH-ILD.
Main Methods:
- Retrospective review of prospectively collected data from 161 ILD patients.
- Stratification of patients into low, intermediate, and high-risk groups using the PH-ILD Detection tool.
- Follow-up echocardiograms and right heart catheterization for intermediate and high-risk groups to confirm PH-ILD diagnosis.
Main Results:
- The PH-ILD Detection tool demonstrated high accuracy, with a sensitivity of 93.3% and specificity of 90.9%.
- The area under the curve (AUC) was 0.921, indicating excellent diagnostic performance.
- PH-ILD was diagnosed in 73.2% of patients identified as high-risk by the tool.
Conclusions:
- The PH-ILD Detection tool is validated in an independent cohort, confirming its reliability for diagnosing PH in ILD patients.
- The tool serves as a fundamental resource for the early recognition of PH in ILD, facilitating prompt management.
