Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

753
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
753
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

1.2K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
1.2K
EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

617
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
617
Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

Parentral Nutrition: Centeral and Peripheral Parental Nutrition

213
Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
PN can be administered through two primary routes:
1. Central Parenteral Nutrition (CPN):
CPN involves delivering a high concentration of nutrients through a large vein. This is typically achieved using a Peripherally Inserted Central Catheter (PICC) or,...
213
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

14
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
14

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flow diversion of a distal M3 segment middle cerebral artery pseudoaneurysm in a pediatric patient: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Synergistic Association of Prematurity and Preoperative Anemia with Neonatal Postoperative Mortality.

Anesthesia and analgesia·2026
Same author

Family Resilience and Mental and Physical Health Sequelae of Pediatric TBI in Youths.

JAMA network open·2026
Same author

Fetoscopic repair of myeloschisis: optimizing the three-layer closure.

Neurosurgical focus: Video·2026
Same author

The Safety and Efficacy of Pipeline Embolization in Pediatric Intracranial Aneurysms: A Systematic Review and Institutional Experience.

Neurosurgery·2026
Same author

Editorial. The Society for Pediatric Neurosurgical Oncology: an alternative view.

Journal of neurosurgery. Pediatrics·2026
Same journal

Drug Administration Patterns in Patients on Extracorporeal Membrane Oxygenation.

Journal of pediatric intensive care·2026
Same journal

Post-Intensive Care Syndrome in a Cohort of School-Aged Children and Adolescent ICU Survivors: The Importance of Follow-up in the Acute Recovery Phase.

Journal of pediatric intensive care·2025
Same journal

Retraction Note: The Effects of Quran Recitation on Sedation and Pain in Children.

Journal of pediatric intensive care·2024
Same journal

Severe Traumatic Brain Injury in French-Speaking Pediatric Intensive Care Units: Study of Practices.

Journal of pediatric intensive care·2024
Same journal

Simulation-Facilitated Education for Pediatric Critical Care Nurse Practitioners' Airway Management Skills: A 10-Year Experience.

Journal of pediatric intensive care·2024
Same journal

A Meta-analysis of the Utility of Red Cell Distribution Width as a Biomarker to Predict Outcomes in Pediatric Illness (PROSPERO CRD42020208777).

Journal of pediatric intensive care·2024
See all related articles

Related Experiment Video

Updated: Jul 19, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.0K

Prothrombin Complex Concentrate Utilization in Children's Hospitals.

Jeffrey E Lutmer1, Christian Mpody2, Eric A Sribnick3

  • 1Division of Pediatric Critical Care Medicine, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, Ohio, United States.

Journal of Pediatric Intensive Care
|August 11, 2023
PubMed
Summary
This summary is machine-generated.

Prothrombin complex concentrates (PCCs) use is rising in critically ill children, often for emergent reasons, not just anticoagulant reversal. Further research is needed on PCC indications, efficacy, and safety in pediatric patients.

Keywords:
anticoagulantsbleedingcoagulopathyprothrombin complex concentrateswarfarin

More Related Videos

In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

712
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

28.8K

Related Experiment Videos

Last Updated: Jul 19, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

19.0K
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

712
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

28.8K

Area of Science:

  • Pediatric Critical Care Medicine
  • Hematology
  • Pharmacovigilance

Background:

  • Prothrombin complex concentrates (PCCs) are crucial for managing bleeding in critically ill children.
  • Understanding PCC utilization patterns and associated risk factors is essential for optimizing pediatric care.

Purpose of the Study:

  • To describe the trends in PCC utilization in U.S. children's hospitals from 2015 to 2020.
  • To determine the relationship between PCC use and specific bleeding risk factors, including anticoagulation and bleeding diatheses.

Main Methods:

  • A repeat cross-sectional study using the Pediatric Health Information System (PHIS) registry.
  • Inclusion of children under 18 years receiving 3-factor or 4-factor PCC between January 2015 and December 2020.
  • Analysis of PCC therapy associations with anticoagulation and bleeding diatheses.

Main Results:

  • PCC utilization increased steadily from 1.3 to 4.6 per 10,000 encounters over the 6-year period.
  • Patients receiving PCC were critically ill (85.0% ICU admission) with a 25.8% mortality rate.
  • PCCs were predominantly used emergently or urgently, more often in surgical than medical cases, and not strongly correlated with anticoagulant use.

Conclusions:

  • PCC use in critically ill children is increasing and not solely for vitamin K antagonist reversal.
  • Current PCC use patterns do not appear to correlate with specific anticoagulant therapies or identified bleeding risk factors.
  • Further investigation into the indications, efficacy, and safety of PCC therapy in pediatric populations is warranted.