Related Experiment Video
Updated: Jul 19, 2025
08:46
Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research
Published on: March 22, 2024
1.3K
Lymphatic vessels and the renin-angiotensin-system
Giovanni Bertoldi1,2, Ilaria Caputo1, Lorenzo Calò2
1Emergency and Hypertension Unit, DIMED, Università degli Studi di Padova, Padova, Italy.
American Journal of Physiology. Heart and Circulatory Physiology
|August 11, 2023
Summary
The renin-angiotensin-system (RAS) may impact lymphatic function, potentially contributing to cardio-reno-vascular (CRV) disease. Further research is needed to understand how RAS affects lymphatic vessels in CRV disease pathogenesis.
Area of Science:
- Cardiovascular Science
- Lymphatic Biology
- Renal Physiology
Background:
- The lymphatic system is crucial for fluid balance and immune function.
- Lymphatic dysfunction is increasingly linked to cardio-reno-vascular (CRV) disease.
- The role of the renin-angiotensin-system (RAS) in lymphatic function remains poorly understood.
Purpose of the Study:
- To review current literature on the link between RAS and lymphatic function.
- To explore potential RAS-specific signaling pathways affecting lymphatic vessels.
- To highlight the implications for CRV disease pathogenesis.
Main Methods:
- Literature review of studies investigating RAS and lymphatic systems.
- Analysis of signaling pathways involved in arterial remodeling and CRV disease.
- Synthesis of evidence linking RAS mediators to lymphatic function and plasticity.
Main Results:
- Evidence suggests RAS influences lymphatic vessel contractility and function.
- RAS-mediated pathways implicated in arterial disease may also affect lymphatics.
- Dysfunctional lymphatic response to RAS could exacerbate CRV disease.
Conclusions:
- The RAS is a potential key modulator of lymphatic vessel function.
- Targeting RAS pathways may offer novel therapeutic strategies for CRV disease.
- Further investigation into RAS-lymphatic interactions is warranted.
Related Concept Videos
01:16Lymphatic Vessels and Lymph Transport
3.7K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
3.7K
01:30Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
690
Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
690
01:20Overview of the Vascular System
2.8K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
2.8K
01:33Hormonal Regulation
33.3K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
33.3K
01:25Antihypertensive Drugs: Direct Renin Inhibitors
682
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
682
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
780
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
780