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Higher Risk of Incident Hyperthyroidism in Patients With Atrial Fibrillation

Pang-Shuo Huang1,2,3, Jen-Fang Cheng3,4,5, Jien-Jiun Chen1

  • 1Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin 640, Taiwan.

The Journal of Clinical Endocrinology and Metabolism
|August 11, 2023
PubMed

Insights

Atrial fibrillation (AF) may predict hyperthyroidism, with younger age and female gender being key risk factors. A new SAD HEC2 score shows predictive power for developing hyperthyroidism in AF patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Epidemiology

Background:

  • Atrial fibrillation (AF) is associated with an elevated risk of hyperthyroidism.
  • The specific factors contributing to this increased risk remain unclear.

Purpose of the Study:

  • To investigate if atrial fibrillation (AF) can predict the development of hyperthyroidism.
  • To identify risk factors associated with hyperthyroidism in patients with AF.

Main Methods:

  • A retrospective cohort study involving 8552 patients diagnosed with AF but without pre-existing hyperthyroidism.
  • Follow-up assessments were conducted to identify new diagnoses of hyperthyroidism.

Main Results:

  • Patients who developed hyperthyroidism were younger and more likely to be female, with fewer comorbidities.
  • Lower CHADS2 scores were observed in patients who developed hyperthyroidism.
  • Independent predictors included younger age, female gender, congestive heart failure, hypertension, diabetes, non-end-stage renal disease (ESRD) status, and lower CHADS2 score.
  • A novel risk score, SAD HEC2, demonstrated excellent predictive capability for incident hyperthyroidism.

Conclusions:

  • Atrial fibrillation (AF) may serve as a precursor to hyperthyroidism.
  • The study identified key clinical risk factors and introduced the SAD HEC2 score for predicting hyperthyroidism in AF patients.
Abstract

Keywords:
Asiaatrial fibrillationhyperthyroidismrisk score

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