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Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms
J Kuneš1, S Hojná, L Mráziková
1Institute of Physiology AS CR, Prague, Czech Republic. kunes@biomed.cas.cz. Research Institute of McGill University Health Centre (RI-MUHC), Québac, Canada, rhian.touyz@mcgill.ca.
Physiological Research
|August 11, 2023
Summary
Obesity, cardiovascular, and neurodegenerative diseases share unclear links and lack effective treatments. This review explores potential common mechanisms, including the gut microbiome, to improve understanding and prevention strategies.
Area of Science:
- Medical Science
- Public Health
- Microbiology
Background:
- Rising global incidence of obesity, cardiovascular diseases (CVD), and neurodegenerative diseases like Alzheimer's disease is linked to lifestyle and aging.
- Interconnections and common underlying mechanisms between these conditions remain unclear.
- Current therapies for obesity and neurodegeneration are insufficient, with limited translation of preclinical findings to clinical practice.
Conclusions:
- Further research is needed to elucidate the common mechanisms linking obesity, CVD, and neurodegeneration.
- Identifying biomarkers for early disease onset is crucial for timely preventive interventions.
- Targeting the gut microbiome may offer novel therapeutic strategies for these prevalent conditions.
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