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Updated: Jul 19, 2025
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Pulse-chase Analysis of N-linked Sugar Chains from Glycoproteins in Mammalian Cells
Published on: April 27, 2010
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Protein O-mannosylation: one sugar, several pathways, many functions.
Melissa Koff1, Pedro Monagas-Valentin1, Boris Novikov1
1Department of Biochemistry and Biophysics, AgriLife Research, Texas A&M University, College Station, College Station, TX 77843, United States.
Glycobiology
|August 11, 2023
Summary
Protein O-mannosylation is vital for nervous system function and development. Defects in this process lead to neurological disorders and muscular dystrophies, highlighting its critical role.
Area of Science:
- Biochemistry and Molecular Biology
- Neuroscience
- Developmental Biology
Background:
- Protein O-mannosylation is a conserved posttranslational modification essential for biological processes.
- Defects in O-mannosylation are linked to severe neurological conditions and congenital muscular dystrophies.
- The precise molecular and cellular mechanisms of O-mannosylation remain largely unelucidated.
Approach:
- This review synthesizes recent findings on protein O-mannosylation.
- It focuses on the role of O-mannosylation in the nervous system.
- It summarizes current knowledge on O-mannosylation biosynthesis and associated pathologies, including insights from Drosophila models.
Key Points:
- Protein O-mannosylation is critical for nervous system development and function.
- O-mannosylation defects result in significant neurological and muscular abnormalities.
- Understanding O-mannosylation biosynthesis is key to addressing associated diseases.
Conclusions:
- Recent research highlights the crucial roles of protein O-mannosylation in health and disease.
- Further investigation is needed to fully understand the molecular and cellular mechanisms of O-mannosylation.
- Addressing knowledge gaps is essential for future therapeutic strategies targeting O-mannosylation-related disorders.
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