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Can Enterococcus faecium prevent NEC in preterm infants?: A systematic review and meta-analysis
Guangguo Men1, Lili Wang2, Xudan Lu3
1Neonatal Intensive Care Unit, Ningbo Women and Children's Hospital, Ningbo, China.
Medicine
|August 11, 2023
Summary
Enterococcus faecium effectively prevents necrotizing enterocolitis (NEC) in preterm infants. This probiotic significantly reduces NEC incidence and infection rates, demonstrating its safety and efficacy.
Area of Science:
- Neonatal Medicine
- Microbiology
- Clinical Research
Background:
- Previous reviews on probiotics for preventing necrotizing enterocolitis (NEC) in preterm infants show mixed results due to varied bacterial strains.
- A comprehensive systematic review specifically assessing Enterococcus faecium for NEC prevention in preterm infants was lacking.
Approach:
- A systematic review and meta-analysis of randomized controlled trials and retrospective studies was conducted.
- Searches were performed across multiple databases (PubMed, Web of Science, Cochrane, EMBASE, Wanfang, CNKI) up to April 14, 2023.
- Included studies focused on preterm infants diagnosed with NEC who received Enterococcus faecium, with data analyzed for efficacy and safety.
Key Points:
- Seven studies with 1487 participants were included; 6 RCTs (1237 participants) were meta-analyzed.
- Enterococcus faecium significantly reduced the incidence of NEC Bell stage II or higher (RR: 0.3138, P < .00001).
- Enterococcus faecium also significantly decreased infection rates (RR: 0.4818, P = .004).
Conclusions:
- Enterococcus faecium is an effective and safe probiotic for preventing NEC (Bell stage II or higher) in preterm infants.
- All included studies originated from China, highlighting a potential geographical limitation.
- Variations in Enterococcus faecium dosage and administration duration were noted across studies.
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