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Stimuli responsive nanosonosensitizers for sonodynamic therapy
Zeyu Jiang1, Wenjing Xiao2, Qinrui Fu3
1Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China; Department of Cardiovascular Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266003, China.
Sonodynamic therapy (SDT) uses ultrasound and sonosensitizers to treat tumors and infections. Responsive nano-sonosensitizers offer a promising, targeted approach to overcome limitations of current SDT methods.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Therapeutics
Background:
- Sonodynamic therapy (SDT) is a promising noninvasive treatment for deep tumors and multidrug-resistant (MDR) bacterial infections.
- Current sonosensitizers (organic and inorganic) face limitations like poor solubility, toxicity, low ROS yield, and insufficient targeting.
- Stimuli-responsive nano-sonosensitizers offer a potential solution by leveraging local microenvironments and ultrasound stimulation.
Purpose of the Study:
- To provide a comprehensive overview of SDT mechanisms.
- To discuss the application of responsive nano-sonosensitizers in treating tumors and bacterial infections.
- To highlight the significance of response patterns in designing effective nano-sonosensitizers.
Main Methods:
- Review of current literature on SDT mechanisms.
- Analysis of responsive nano-sonosensitizer design principles.
- Classification and discussion of various response patterns.
Main Results:
- Detailed explanation of SDT mechanisms, including ROS generation and external damage.
- Demonstration of responsive nano-sonosensitizers' potential in preclinical tumor and infection models.
- Emphasis on the importance of stimuli-responsive designs for enhanced efficacy and safety.
Conclusions:
- Responsive nano-sonosensitizers represent a significant advancement over traditional sonosensitizers for SDT.
- Further research and development are needed to address limitations and promote clinical translation of SDT.
- Optimizing stimuli-responsive strategies is crucial for efficient, specific, and safe therapeutic outcomes.
