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Updated: Jul 19, 2025

Real-time Electrophysiology: Using Closed-loop Protocols to Probe Neuronal Dynamics and Beyond
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Hyperpolarization-Activated Cation Channels Shape the Spiking Frequency Preference of Human Cortical Layer 5

Happy Inibhunu1, Homeira Moradi Chameh1, Frances Skinner1,2

  • 1Division of Clinical and Computational Neuroscience, Krembil Brain Institute, University Health Network, Toronto, Ontario M5T 1M8, Canada.

Eneuro
|August 11, 2023
PubMed
Summary

Researchers studied human neurons to understand how ionic currents affect spiking frequency preference. They found unique dynamics of the hyperpolarization-activated cyclic nucleotide gated (h-) current in human neurons, impacting their electrical activity.

Keywords:
computational neurosciencecortexfrequency-dependent gainh-channelhuman neuron modelinglayer 5 pyramidal cell

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