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Related Concept Videos

Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Thermoregulation01:26

Thermoregulation

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The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
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Diversity of Archaea IV01:29

Diversity of Archaea IV

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Hyperthermophilic archaea are a group of extremophiles thriving at temperatures above 80°C, often in hydrothermal vents and volcanic soils where conditions surpass the boiling point of water. At such temperatures, proteins, membranes, and DNA in most organisms degrade, but hyperthermophiles have evolved remarkable adaptations to maintain stability and function.Unique Cellular FeaturesHyperthermophilic membranes are composed of a monolayer of biphytanyl tetraether lipids, which resist...
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Hyperthermia-triggered biomimetic bubble nanomachines.

Junbin Gao1, Hanfeng Qin1, Fei Wang1

  • 1NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.

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|August 11, 2023
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Biomimetic nanodevices release smaller vesicles for enhanced tumor penetration. This approach improves synergistic photothermal and photodynamic cancer therapy by overcoming biological barriers.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Nanoparticle drug delivery faces challenges with tumor penetration due to the tumor microenvironment.
  • Effective cancer treatment requires overcoming biological barriers to enhance nanomedicine efficacy.

Purpose of the Study:

  • To develop novel biomimetic nanodevices for improved tumor penetration and synergistic cancer therapy.
  • To create a nanoplatform capable of in-situ generation of smaller nanovesicles for enhanced drug delivery.

Main Methods:

  • Fabrication of porous gold nanocages (AuNC) loaded with perfluorohexane (PFO) and hemoglobin (Hb).
  • Camouflage of AuNC with 4T1 tumor cell membrane, pre-saturated with oxygen and anchored with indocyanine green (ICG).
  • NIR laser irradiation to trigger PFO phase transition, inducing nanovesicle budding for enhanced therapy.

Main Results:

  • NIR laser irradiation induced the formation of smaller, cell-membrane-derived nanovesicles.
  • The generated nanovesicles exhibited enhanced tumor penetration.
  • The nanodevices demonstrated synergistic photothermal and photodynamic therapy with self-sufficient oxygen supply.

Conclusions:

  • The developed biomimetic nanodevices show promise as a temperature-responsive nanoplatform for cancer treatment.
  • This approach offers a strategy to overcome tumor penetration limitations in nanomedicine.
  • The synergistic therapeutic effects highlight the potential for improved cancer therapy outcomes.