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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
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Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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[Antibiotic stewardship].

Miriam Stegemann1

  • 1Klinik für Infektiologie und Intensivmedizin, Fächerverbund für Infektiologie, Pneumologie und Intensivmedizin, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland. miriam.stegemann@charite.de.

Medizinische Klinik, Intensivmedizin Und Notfallmedizin
|August 11, 2023
PubMed
Summary

Antimicrobial resistance (AMR) is a major global health threat. Implementing antibiotic stewardship (AMS) principles and optimizing antimicrobial use are crucial to combat AMR and improve patient care, especially in sepsis.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Pharmacology
Keywords:
Anti-infective agentsAntibioticsAntimicrobial resistanceDrug utilization reviewEvaluation

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