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Air pollution is associated with abnormal left ventricular diastolic function: a nationwide population-based study.

Congyi Zheng1, Haosu Tang2,3, Xin Wang1

  • 1Division of Prevention and Community Health, National Center for Cardiovascular Disease, National Clinical Research Center of Cardiovascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 15 (Lin), Fengcunxili, Mentougou District, Beijing, 102308, China.

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Air pollution from PM2.5, PM10, and NO2 is linked to abnormal left ventricular diastolic function (ALVDF). This finding highlights the need for interventions to reduce air pollution for better cardiovascular health.

Keywords:
Air pollutionCardiac dysfunctionParticulate matterPopulationRisk factor

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Area of Science:

  • Environmental Health
  • Cardiology
  • Public Health

Background:

  • Air pollution poses a significant global public health risk.
  • Limited research exists on the connection between air pollutants and cardiac imaging.
  • This study investigates ambient air pollution's impact on left ventricular diastolic function.

Purpose of the Study:

  • To explore the association between ambient air pollution and abnormal left ventricular diastolic function (ALVDF).
  • To analyze data from a large-scale, representative population in China.

Main Methods:

  • Utilized data from the China Hypertension Survey (CHS) (2012-2015) with 25,983 participants.
  • Assessed annual average concentrations of PM2.5, PM10, and NO2.
  • Evaluated left ventricular diastolic function using echocardiography based on 2009 guidelines.

Main Results:

  • Elevated PM2.5, PM10, and NO2 levels were associated with increased odds of ALVDF.
  • PM2.5 and PM10 exposure significantly increased the risk of Grade I ALVDF.
  • A positive linear and 'J' shaped concentration-response relationship was observed between PM2.5/NO2 and ALVDF risk.

Conclusions:

  • Ambient PM2.5, PM10, and NO2 are significantly associated with ALVDF, particularly mild forms.
  • This link may explain increased cardiovascular morbidity and mortality linked to air pollution.
  • Interventions to reduce air pollution are crucial for public health in China.