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Predictive Factors for Decreasing Left Ventricular Ejection Fraction and Progression to the Dilated Phase of

Kakeru Ishihara1, Yoshiaki Kubota1, Junya Matsuda1

  • 1Department of Cardiovascular Medicine, Nippon Medical School, Tokyo 113-0022, Japan.

Journal of Clinical Medicine
|August 12, 2023
PubMed

Insights

Predictors of dilated phase hypertrophic cardiomyopathy (DHCM) include atrial fibrillation, nonsustained ventricular tachycardia, and left ventricular diameter. These factors help identify patients at higher risk for DHCM progression.

Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Hypertrophic cardiomyopathy (HCM) can progress to a dilated phase (DHCM).
  • Identifying predictors of DHCM is crucial for patient management and prognosis.

Purpose of the Study:

  • To identify predictive factors for DHCM progression in HCM patients.
  • To investigate the impact of percutaneous transluminal septal myocardial ablation (PTSMA) on DHCM development.

Main Methods:

  • Retrospective analysis of 291 HCM patients from a hospital registry.
  • Grouped patients based on post-study left ventricular ejection fraction (LVEF).
  • Multivariate analysis to determine predictors of DHCM (LVEF < 50% or < 60%).

Main Results:

  • Atrial fibrillation (AF), nonsustained ventricular tachycardia (NSVT), and left ventricular end-systolic diameter (LVDs) were significant predictors of DHCM.
  • A scoring system based on AF, NSVT, and LVDs identified patients at significantly higher risk.
  • PTSMA did not significantly affect long-term LVEF or DHCM development in 78 patients.

Conclusions:

  • AF, NSVT, and LVDs are key predictors for DHCM development.
  • A validated scoring system could aid in risk stratification.
  • Further validation in larger cohorts is necessary.

Keywords:
dilated phase of hypertrophic cardiomyopathyejection fractionhypertrophic cardiomyopathy

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