Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.7K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Image Matching for UAV Geolocation: Classical and Deep Learning Approaches.

Journal of imaging·2025
Same author

Fibre tracing in biomedical images: An objective comparison between seven algorithms.

PloS one·2025
Same author

Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis.

Nature communications·2025
Same author

Volumetric Semantic Instance Segmentation of the Plasma Membrane of HeLa Cells.

Journal of imaging·2024
Same author

Impact of Training Data, Ground Truth and Shape Variability in the Deep Learning-Based Semantic Segmentation of HeLa Cells Observed with Electron Microscopy.

Journal of imaging·2023
Same author

Comparison of Convolutional Neural Networks and Transformers for the Classification of Images of COVID-19, Pneumonia and Healthy Individuals as Observed with Computed Tomography.

Journal of imaging·2022

Related Experiment Video

Updated: Jul 19, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.4K

Modelling the Tumour Microenvironment, but What Exactly Do We Mean by "Model"?

Constantino Carlos Reyes-Aldasoro1

  • 1Department of Computer Science, City, University of London, London EC1V 0HB, UK.

Cancers
|August 12, 2023
PubMed
Summary
This summary is machine-generated.

The term "model" in tumor microenvironment research has diverse meanings. While animal models are common, mathematical and computational models are increasingly utilized for cancer research.

Keywords:
computational modelin vitro modelin vivo modelmathematical modelmodel organismtumour microenvironment

More Related Videos

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

4.8K
Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

7.3K

Related Experiment Videos

Last Updated: Jul 19, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

10.4K
Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

4.8K
Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography
09:53

Quantifying the Brain Metastatic Tumor Micro-Environment using an Organ-On-A Chip 3D Model, Machine Learning, and Confocal Tomography

Published on: August 16, 2020

7.3K

Area of Science:

  • Oncology
  • Bioinformatics
  • Scientific Methodology

Background:

  • The term "model" in scientific research, particularly in cancer studies, lacks a singular definition.
  • Context is crucial for understanding "model," ranging from physical replicas to abstract representations.
  • Tumor microenvironment research encompasses various interpretations of "model," including animal, in vitro, mathematical, and computational approaches.

Purpose of the Study:

  • To review and categorize different types of "models" used in tumor microenvironment research.
  • To quantitatively assess the frequency and trends of various "model" types in the MEDLINE database.
  • To analyze the usage of specific keywords related to cancer types and microenvironment components within different model categories.

Main Methods:

  • Literature review categorizing tumor microenvironment models into four types: model organisms, in vitro, mathematical, and computational.
  • Quantitative analysis of MEDLINE database entries using specific keywords to determine model frequencies.
  • Assessment of trends in the usage of different model types over time.

Main Results:

  • Animal models, especially xenografts and mouse models, are historically prevalent but show a declining trend.
  • Mathematical models, including prognostic and risk models, are increasing in frequency and application.
  • The study quantifies the usage of various model types and associated cancer research keywords.

Conclusions:

  • The definition and application of "models" in tumor microenvironment research are diverse and evolving.
  • There is a discernible shift from traditional animal models towards mathematical and computational approaches in cancer research.
  • Quantitative analysis of research literature provides insights into the changing landscape of tumor microenvironment modeling techniques.