Recent Advances in Clinical Research for Skin Cancer Chemoprevention

Area of Science:

• Oncology
• Dermatology
• Preventive Medicine

Background:

• Skin cancer, including neoplasms of keratinocytes and melanocytes, is a leading global cancer.
• Ultraviolet (UV) radiation is a known risk factor, leading to preventive strategies like sunscreens, though their efficacy is debated.
• Chemoprevention, using natural or synthetic compounds, offers an alternative strategy to inhibit or reverse skin cancer development, with promising preclinical data.

Purpose of the Study:

• To review recent clinical trials on chemopreventive agents for skin cancer.
• To compare target populations, interventions, endpoints, and outcomes of these trials.
• To provide updated information on the efficacy and side effects of promising chemopreventive agents in human subjects and identify research gaps.

Main Methods:

• Searched ClinicalTrials and PubMed databases.
• Used keywords "skin cancer" and "chemoprevention".
• Evaluated literature on clinical trials investigating chemopreventive agents for skin cancer.

Main Results:

• The review synthesizes findings from clinical trials on various chemopreventive agents.
• Identified commonalities and differences in trial designs, interventions, and outcomes.
• Highlighted the current understanding of effectiveness and side effects in human subjects.

Conclusions:

• Clinical application of chemopreventive agents for skin cancer requires further investigation.
• Translating preclinical findings into effective clinical strategies remains a challenge.
• Continued research is needed to identify optimal chemopreventive agents and strategies for skin cancer prevention.