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Metabolites and Immune Response in Tumor Microenvironments
Salvatore Cortellino1, Valter D Longo2,3
1Laboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, 85028 Rionero in Vulture, Italy.
Cancers
|August 12, 2023
Summary
Dietary interventions like amino acid restriction and fasting can combat cancer's immunosuppressive tumor microenvironment. These strategies modulate hormones and cytokines, potentially enhancing cancer therapy by improving immune response.
Area of Science:
- Oncology
- Immunology
- Metabolism
Background:
- Cancer cell metabolism significantly alters the tumor microenvironment, fostering an immunosuppressive state.
- This metabolic reprogramming involves changes in nutrient levels and the release of signaling molecules that attract immunosuppressive immune cells.
Purpose of the Study:
- To review the latest research on dietary interventions impacting cancer immunometabolism and immune response.
- To explore the potential of dietary strategies in augmenting cancer therapy.
Main Methods:
- Discussion of current research findings on amino acid restriction and fasting-mimicking diets.
- Analysis of the systemic effects of these diets on hormones, growth factors, cytokines, and tumor microenvironment components.
Main Results:
- Dietary interventions can prevent or reduce the immunosuppressive tumor microenvironment.
- These interventions act systemically, influencing hormone release, cytokine production, and tumor vasculature.
Conclusions:
- Novel dietary interventions show promise in modulating the tumor immune response.
- Dietary strategies could become a valuable component of future cancer treatment regimens.
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