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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
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Rapid Progressive Fatal Acute Hemorrhagic Encephalomyelitis
Ssu-Yu Chen1, Hung-Chieh Chen2,3, Ting-Bin Chen3,4,5,6
1School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Diagnostics (Basel, Switzerland)
|August 12, 2023
Summary
Acute hemorrhagic encephalomyelitis (AHEM), a severe form of ADEM, has a high mortality rate. This case study details a fatal AHEM progression despite intensive immune therapy, offering insights for future management.
Area of Science:
- Neurology
- Immunology
- Pathology
Background:
- Acute hemorrhagic encephalomyelitis (AHEM) is the most severe variant of acute disseminated encephalomyelitis (ADEM).
- AHEM is characterized by a high mortality rate and poor patient outcomes.
- Rapid progression and severe neurological deficits are hallmarks of AHEM.
Purpose of the Study:
- To present a case of a middle-aged male diagnosed with AHEM.
- To illustrate the rapid clinical course and serial brain imaging changes in AHEM.
- To offer insights into the management challenges and outcomes of AHEM.
Main Methods:
- Case report of a middle-aged male patient with AHEM.
- Documentation of clinical course and symptoms.
- Serial magnetic resonance imaging (MRI) to track brain parenchyma changes.
Main Results:
- The patient was diagnosed with AHEM and received intensive immune therapy.
- Despite treatment, the patient experienced rapid disease progression.
- The patient unfortunately died 35 days after admission.
Conclusions:
- AHEM presents a severe clinical challenge with a high mortality rate.
- Intensive immune therapy may not always alter the unfavorable outcome of AHEM.
- Further research is needed to improve AHEM diagnosis and therapeutic strategies.
