Generalized Polyspike Pattern in EEG Due to Aseptic Meningoencephalitis.

Area of Science:

• Neurology
• Neurophysiology

Background:

• Aseptic meningoencephalitis can present with diverse neurological symptoms.
• Electroencephalography (EEG) is crucial for diagnosing and monitoring seizure disorders and encephalitic processes.

Purpose of the Study:

• To report a case of aseptic meningoencephalitis presenting with specific EEG findings.
• To illustrate the resolution of EEG abnormalities following appropriate treatment.

Main Methods:

• Case report of a 71-year-old patient.
• Electroencephalography (EEG) for neurophysiological assessment.
• Cerebrospinal fluid (CSF) analysis.
• Brain imaging.
• Therapeutic intervention including antibiotics, antivirals, and anticonvulsants.

Main Results:

• The patient exhibited word-finding difficulties, generalized tonic-clonic seizures, and sopor.
• EEG revealed an intermittent generalized polyspike pattern.
• CSF analysis showed pleocytosis (99 leukocytes/μL, predominantly neutrophils) and elevated protein (1240 mg/L).
• No pathogens or autoimmune antibodies were detected in CSF; brain imaging was unremarkable.
• Post-treatment, EEG abnormalities resolved, and the patient showed no residual deficits.

Conclusions:

• Aseptic meningoencephalitis can manifest with significant EEG abnormalities, such as generalized polyspike patterns.
• Prompt and comprehensive treatment can lead to the resolution of neurological symptoms and EEG findings.
• This case highlights the importance of EEG in diagnosing and managing inflammatory brain conditions.