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Mitogen-Activated Protein Kinases (MAPKs) and Enteric Bacterial Pathogens: A Complex Interplay

Ipsita Nandi1, Benjamin Aroeti1

  • 1Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 9190410, Israel.

International Journal of Molecular Sciences
|August 12, 2023
PubMed

Insights

Enteric bacterial pathogens manipulate host mitogen-activated protein kinase (MAPK) signaling pathways. Understanding these bacterial strategies is key to developing novel MAPK-targeted antimicrobial therapies.

Area of Science:

  • Molecular Biology
  • Immunology
  • Microbiology

Background:

  • Mitogen-activated protein kinases (MAPKs) are crucial intracellular signaling pathways regulating diverse cellular activities, including innate immune responses.
  • Bacterial pathogens, particularly enteric bacteria, can interfere with host MAPK signaling to evade immune defenses and establish infection.

Purpose of the Study:

  • To review the sophisticated strategies employed by enteric bacterial pathogens to modulate host MAPK signaling cascades.
  • To discuss how these bacterial manipulations impact host innate immunity and contribute to pathogenicity.
  • To explore emerging therapeutic approaches targeting MAPK pathways for antimicrobial treatment.

Main Methods:

  • Review of existing literature on bacterial effector proteins and toxins.
  • Analysis of host-pathogen interactions at the molecular and cellular levels.
  • Discussion of findings related to MAPK pathway modulation by bacterial virulence factors.

Main Results:

  • Enteric bacteria deliver effector proteins and toxins that subvert host MAPK signaling, inactivating or activating key components.
  • These pathogen-driven alterations in MAPK cascades facilitate bacterial colonization, dissemination, and pathogenesis.
  • Host pattern recognition receptors (PRRs) and subsequent MAPK/NF-κB activation are common targets for bacterial interference.

Conclusions:

  • Enteric bacterial pathogens possess diverse mechanisms to manipulate host MAPK signaling, highlighting a critical aspect of host-pathogen interplay.
  • Targeting MAPK pathways represents a promising strategy for developing novel antimicrobial therapies against challenging bacterial infections.
Keywords:
MAP kinasesMAPK inhibitorsanti-microbial treatmentscholera toxinsdiarrheal diseasesenteric bacterial pathogenshost-pathogen interactionsinflammatory responsestype III secreted effectors

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