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Measurement of Insulin- and Contraction-Stimulated Glucose Uptake in Isolated and Incubated Mature Skeletal Muscle from Mice
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Sexual Dimorphism in Cardiometabolic Diseases: The Role of AMPK

Miroslava Kvandova1, Angelika Puzserova1, Peter Balis1

  • 1Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 841 04 Bratislava, Slovakia.

International Journal of Molecular Sciences
|August 12, 2023
PubMed

Insights

Sex hormones influence metabolic syndrome and cardiovascular diseases (CVDs). Understanding the cross-talk between AMP-dependent protein kinase (AMPK) and sex hormones offers insights into sex-specific prevention and treatment strategies for CVDs.

Area of Science:

  • Endocrinology
  • Cardiology
  • Metabolic Health

Background:

  • Cardiovascular diseases (CVDs) are a leading cause of mortality globally.
  • Metabolic syndrome, characterized by obesity and related factors like hypertension and dysregulated glucose/lipid metabolism, significantly increases CVD risk.
  • Sex hormones play a role in metabolic regulation and sex-specific susceptibility to obesity, necessitating tailored management approaches.

Purpose of the Study:

  • To review the interplay between AMP-dependent protein kinase (AMPK) and sex hormones.
  • To explore the role of this interaction in cardiometabolic disease development and progression.
  • To identify potential therapeutic targets for human diseases.

Main Methods:

  • Literature review of existing research on AMPK, sex hormones, and cardiometabolic health.
  • Analysis of studies investigating the regulatory mechanisms between AMPK and sex hormones.
  • Synthesis of findings related to cardiovascular protection and anti-diabetic properties.

Main Results:

  • AMPK exhibits protective effects in the cardiovascular system and possesses anti-diabetic properties.
  • Sex hormones regulate AMPK activity, influencing metabolic processes.
  • The cross-talk between AMPK and sex hormones is a critical factor in cardiometabolic disease.

Conclusions:

  • AMPK activation holds potential cardiometabolic benefits.
  • Understanding the sex-specific regulation of AMPK by sex hormones is crucial for developing targeted therapies.
  • This interaction represents a promising target for the primary and secondary prevention of cardiovascular diseases.

Keywords:
AMPKandrogen signalingcardiovascular diseasesendothelial functionestrogen signalingmetabolic regulationsexual dimorphism

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