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Related Concept Videos

Fatigue01:21

Fatigue

206
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
206
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

291
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
291
T Cell Types and Functions01:24

T Cell Types and Functions

1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

2.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.2K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

355
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
355

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Fatigue in Inflammatory Joint Diseases.

Grzegorz Chmielewski1, Michał S Majewski2, Jakub Kuna1

  • 1Department of Rheumatology, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-900 Olsztyn, Poland.

International Journal of Molecular Sciences
|August 12, 2023
PubMed
Summary
This summary is machine-generated.

Fatigue is a common, yet underestimated, symptom in rheumatic diseases like rheumatoid arthritis. Effectively managing this subjective exhaustion requires a comprehensive approach focusing on individual patient experiences.

Keywords:
cytokinesfatigueinflammationinflammatory joint diseases

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Area of Science:

  • Rheumatology
  • Symptomology
  • Patient-Reported Outcomes

Background:

  • Fatigue is a prevalent and debilitating symptom in rheumatic diseases, including rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
  • It significantly impacts patients' quality of life and exacerbates disability, despite often being underestimated in clinical practice.
  • The multifaceted nature of fatigue involves physiological, psychological, and social factors, with chronic inflammation a suspected contributor.

Purpose of the Study:

  • To highlight the prevalence and impact of fatigue in rheumatic diseases.
  • To emphasize the need for better clinical recognition and management of fatigue.
  • To underscore the importance of assessing subjective patient experiences in managing fatigue.

Main Methods:

  • Review of the characteristics and contributing factors of fatigue in rheumatic diseases.
  • Discussion of the limitations of objective clinical evaluation for subjective symptoms like fatigue.
  • Emphasis on the necessity of a multifaceted approach to fatigue management.

Main Results:

  • Fatigue is a common, subjective symptom in inflammatory joint diseases that is often underestimated.
  • Current treatments may reduce inflammation but do not always resolve fatigue.
  • Assessing the subjective components of fatigue is crucial for effective management.

Conclusions:

  • Fatigue is a significant and complex symptom in rheumatic diseases that requires greater clinical attention.
  • A comprehensive, patient-centered approach is essential for managing fatigue effectively.
  • Recognizing and addressing the subjective nature of fatigue is key to improving patient outcomes.