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Prostaglandin E2 (PGE2) and Roflumilast Involvement in IPF Progression

Noa Moshkovitz1, Gali Epstein Shochet1, David Shitrit1,2

  • 1Pulmonary Department, Meir Medical Center, Kfar Saba 44281, Israel.

International Journal of Molecular Sciences
|August 12, 2023
PubMed
Summary

A novel in vitro model of idiopathic pulmonary fibrosis (IPF) shows that Roflumilast, a PDE4 inhibitor, can block lung scarring processes. This suggests targeting PGE2/PDE4 signaling may treat IPF progression.

Keywords:
IPFPGE2Roflumilastextracellular matrixfibroblast

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