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Identification of Bacterial Metabolites Modulating Breast Cancer Cell Proliferation and Epithelial-Mesenchymal
Gyula Ujlaki1, Tünde Kovács1, András Vida1
1Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Molecules (Basel, Switzerland)
|August 12, 2023
Summary
Breast cancer alters the gut microbiome, reducing antineoplastic metabolites. This study identified specific bacterial metabolites, like 2,3-butanediol, that inhibit cancer cell growth and migration.
Area of Science:
- Microbiology
- Oncology
- Metabolomics
Background:
- Breast cancer is linked to gut microbiome dysbiosis, impacting the production of beneficial antineoplastic (cancer-fighting) bacterial metabolites.
- Understanding these microbial metabolites is crucial for developing novel therapeutic strategies against breast cancer.
Purpose of the Study:
- To identify specific bacterial metabolites with antineoplastic properties, including effects on cancer cell proliferation and epithelial-mesenchymal transition (EMT).
Main Methods:
- A library of 30 bacterial metabolites was screened for their effects on 4T1 murine breast cancer cells.
- Compounds were tested at concentrations reflecting reference serum levels to assess impact on cell proliferation and EMT.
Main Results:
- Several metabolites exhibited cytostatic (inhibiting cell growth) or hyperproliferative (promoting cell growth) effects.
- Specific metabolites, including 3-hydroxyphenylacetic acid and 2,3-butanediol, were found to inhibit EMT, a process crucial for cancer metastasis.
- 2,3-butanediol demonstrated both cytostatic and anti-EMT properties, making it a promising candidate.
Conclusions:
- Bacterial metabolites play a significant role in breast cancer progression and can be targeted for therapeutic intervention.
- 2,3-butanediol is a key metabolite with dual action against breast cancer cell proliferation and EMT, warranting further investigation.
Keywords:
2,3-butanediol3-hydroxyphenylacetic acid4-hydroxybenzoic acidbacterial metabolitebreast cancerbutyric acidd-mannitoldysbiosisepithelial-mesenchymal transitionglycolic acidhigh content screeninghydrocinnamic acidmetabolite signalingmicrobiomeproliferationsecretometrans-ferulic acidvanillic acidMore Related Videos
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