Bismuth Oxide Composite-Based Agricultural Waste for Wound Dressing Applications

Area of Science:

• Materials Science
• Biomedical Engineering
• Nanotechnology

Background:

• Sugarcane bagasse is a sustainable waste material.
• Developing novel antimicrobial materials is crucial for healthcare.
• Bismuth oxide (Bi2O3) exhibits antimicrobial properties.

Purpose of the Study:

• To enhance the antimicrobial activity of bagasse paper using bismuth oxide (Bi2O3) coatings.
• To evaluate the efficacy of Bi2O3-coated bagasse paper in accelerating wound healing.
• To investigate the antimicrobial and wound healing potential of a novel biomaterial.

Main Methods:

• Bagasse paper sheets were prepared from sugarcane waste.
• Paper sheets were coated with varying concentrations of bismuth oxide (Bi2O3).
• In vitro antimicrobial activity was tested against Gram-negative and Gram-positive bacteria.
• Wound healing potential was assessed in a rat model over 14 days.

Main Results:

• Bi2O3-coated bagasse paper demonstrated significant antimicrobial activity against tested bacteria.
• The highest inhibitory effect was observed with 100% Bi2O3 coating.
• Wound healing assays in rats indicated accelerated healing with Bi2O3-coated paper.
• In vitro studies showed Bi2O3 inhibited cellular migration.

Conclusions:

• Coating bagasse paper with bismuth oxide (Bi2O3) effectively enhances its antimicrobial properties.
• Bi2O3-coated bagasse paper shows promise for accelerating wound healing by reducing infection.
• This novel biomaterial offers a sustainable and effective approach for wound management.