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Chitosan-Based Films Containing Rutin for Potential Cosmetic Applications
Alina Sionkowska1, Katarzyna Lewandowska1, Marzanna Kurzawa2
1Department of Biomaterials and Cosmetic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarin 7 Street, 87100 Torun, Poland.
Polymers
|August 12, 2023
Summary
This study explored chitosan-based films with hyaluronic acid and rutin for cosmetic use. The developed chitosan-rutin mask demonstrated potential for improving skin elasticity and moisturization.
Area of Science:
- Biomaterials Science
- Cosmetic Science
- Polymer Chemistry
Background:
- Chitosan, a polysaccharide, possesses film-forming capabilities utilized in cosmetic and wound-healing applications.
- Hyaluronic acid and rutin are incorporated for potential synergistic effects in cosmetic formulations.
Purpose of the Study:
- To investigate the potential of chitosan-based films containing hyaluronic acid and rutin for cosmetic applications.
- To evaluate the structural, surface, and drug release properties of these films.
- To assess the efficacy of the chitosan-rutin mask on skin properties like elasticity and moisturization.
Main Methods:
- Fabrication of chitosan-based thin films with added rutin.
- Characterization using Fourier-Transform Infrared (FTIR) spectroscopy and Atomic Force Microscopy (AFM).
- Rutins release kinetics studied via High-Performance Liquid Chromatography (HPLC).
- Skin properties (elasticity, moisturization) evaluated using the Aramo TS 2 apparatus.
Main Results:
- Rutin addition influenced the thermal stability and increased the surface roughness of chitosan films without altering the core structure.
- The chitosan-rutin mask showed moderate improvements in skin elasticity and moisturization.
- Rutins maximum release occurred at pH 5.5 within 20 minutes, aligning with physiological skin pH.
- Films containing hyaluronic acid exhibited a lower rutin release rate compared to those without.
Conclusions:
- Chitosan-based films incorporating rutin and hyaluronic acid show promise for cosmetic applications, particularly as moisturizing and elasticity-enhancing masks.
- The release profile of rutin is favorable for topical application, with optimal release at skin-relevant pH.
- Further research could optimize formulations for enhanced delivery and efficacy.
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