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A Hyperbranched Polyol Process for Designing and Manufacturing Nontoxic Cobalt Nanocomposite
Anastasia Burmatova1, Artur Khannanov1, Alexander Gerasimov1
1A.M. Butlerov Chemical Institute, Kazan Federal University, 18 Kremlyovskaya Str., 420008 Kazan, Russia.
Polymers
|August 12, 2023
Summary
A novel method synthesizes cobalt nanoparticle (CoNP) composites using hyperbranched polyols, acting as both reducing and stabilizing agents. These stable, multifunctional CoNPs show promise as T1 contrast agents and possess therapeutic antimycotic and enzyme-modulating properties for theranostics.
Area of Science:
- Materials Science
- Nanotechnology
- Polymer Chemistry
Background:
- Development of advanced nanomaterials for theranostic applications is crucial.
- Metal-polymer nanocomposites offer unique properties but require controlled synthesis.
- Hyperbranched polyols present potential as multifunctional synthesis agents.
Purpose of the Study:
- To develop a method for synthesizing cobalt nanoparticle (CoNP) metallopolymer composites.
- To characterize the CoNPs and evaluate their theranostic potential.
- To investigate the role of hyperbranched polyols in nanoparticle formation and stabilization.
Main Methods:
- Synthesis of CoNPs using the hyperbranched polyol process.
- Characterization via FT-IR, UV-Vis spectroscopy, NTA, TG, XRD, and NMR relaxation.
- In vitro biological testing for hemotoxicity, enzyme modulation, and antimycotic activity.
Main Results:
- Successfully synthesized stable CoNPs (5-7 nm) within spheroid polymer aggregates (35-50 nm).
- CoNPs demonstrated T1 contrast agent properties (R2/R1 ratio = 0.61).
- CoNPs exhibited non-hemotoxicity, modulated chymosin aspartic proteinase activity, and showed antimycotic effects against Aspergillus fumigatus.
Conclusions:
- The hyperbranched polyol process is effective for creating stable, multifunctional CoNPs.
- Synthesized CoNPs are promising theranostic agents with imaging and therapeutic capabilities.
- This two-component method offers a versatile platform for designing advanced metal-polymer nanocomposites.
