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Palatable Western-style Cafeteria Diet as a Reliable Method for Modeling Diet-induced Obesity in Rodents
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Cafeteria Diet-Induced Obesity Worsens Experimental CKD

Jonas Laget1, Irene Cortijo1, Juliana H Boukhaled1

  • 1RD-Néphrologie, 34090 Montpellier, France.

Nutrients
|August 12, 2023
PubMed

Insights

Obesity exacerbates chronic kidney disease (CKD) progression. Pre-existing obesity worsened kidney inflammation and fibrosis after 5/6th nephrectomy in rats, with elevated collagen and macrophage markers.

Area of Science:

  • Nephrology
  • Metabolic Disease Research
  • Pathology

Background:

  • Obesity is a major risk factor for chronic kidney disease (CKD).
  • Understanding how obesity impacts CKD progression is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the effect of obesity on kidney fibrosis development in a rat model.
  • To analyze the expression of specific fibrotic markers and inflammatory cells in obese rats undergoing nephrectomy.

Main Methods:

  • Utilized a rat model with 5/6th nephrectomy (SNx) and a cafeteria diet to induce obesity.
  • Quantified collagen types (1, 3, 4), adipocyte size, macrophage infiltration, and adipokine levels in kidney and epididymal white adipose tissue (eWAT).

Main Results:

  • Obese rats (Cafeteria-SNx) showed significantly increased renal collagen 3 and 4 expression compared to controls.
  • A notable increase in kidney macrophage infiltration was observed in the Cafeteria-SNx group.
  • Elevated levels of specific adipokines, including Interleukin 11 (IL11), dipeptidyl peptidase 4 (DPP4), and serpin 1, were found in obese, nephrectomized rats.

Conclusions:

  • Pre-existing obesity exacerbates CKD-induced renal inflammation and fibrosis.
  • IL11, DPP4, and serpin 1 may play direct roles in promoting fibrosis and worsening kidney disease in obese individuals.
  • Targeting these adipokines could offer a therapeutic strategy for managing CKD in obese patients.
Keywords:
adipokinechronic kidney diseasecollagenfibrosisinflammationmacrophageobesity

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