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Dietary Polyphenols Remodel DNA Methylation Patterns of NRF2 in Chronic Disease

Srinivasaragavan Divyajanani1, Kannan Harithpriya1, Kumar Ganesan2

  • 1Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603210, Tamil Nadu, India.

Nutrients
|August 12, 2023
PubMed

Insights

Nuclear factor erythroid 2-related factor 2 (NRF2) regulates cellular processes. Epigenetic modifications, like DNA methylation, can alter NRF2 expression, offering therapeutic targets for diseases through phytochemical activation.

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Cellular Homeostasis

Background:

  • Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor regulating cellular antioxidant and anti-inflammatory responses.
  • NRF2 activity is modulated by genetic and epigenetic mechanisms, including DNA methylation.
  • Aberrant NRF2 methylation patterns are linked to various diseases.

Purpose of the Study:

  • To review the role of NRF2 in cellular homeostasis and disease.
  • To explore the epigenetic regulation of NRF2, particularly DNA methylation.
  • To discuss the potential of natural phytochemicals in modulating NRF2 activity for therapeutic benefit.

Main Methods:

  • Literature review of studies on NRF2 regulation and function.
  • Analysis of research on epigenetic modifications affecting NRF2 expression.
  • Compilation of data on phytochemicals that activate NRF2.

Main Results:

  • Promoter hypermethylation of NRF2 has been shown to downregulate its expression.
  • Epigenetic changes affecting NRF2 are potentially reversible, unlike genetic mutations.
  • Numerous natural compounds, including sulforaphane and resveratrol, activate NRF2.

Conclusions:

  • Reversing hypermethylated NRF2 states via epigenetic modifications presents therapeutic opportunities.
  • Dietary phytochemistry can influence the human epigenome and NRF2 signaling.
  • Targeting NRF2 offers a promising strategy for preventing and treating chronic disorders.
Keywords:
DNMTsdietary polyphenolsepigeneticshypermethylationhypomethylationnuclear factor erythroid 2-related factor 2phytochemicals

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