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Effects of Omega-3 Fatty Acids on Postoperative Inflammatory Response: A Systematic Review and Meta-Analysis
Ghaith Mohsen1, Annika Stroemer2, Andreas Mayr2
1Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.
Preoperative omega-3 fatty acids (FAs) did not significantly reduce postoperative inflammation or hospital stay in abdominal surgery patients. More research is needed due to inconclusive results from limited trials.
Area of Science:
- Surgical Nutrition
- Immunonutrition
- Clinical Trials
Background:
- Preoperative omega-3 fatty acids (FAs) may reduce postoperative inflammation.
- The impact of omega-3 FAs (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) on inflammatory response after abdominal surgery remains unclear.
- This study investigates the effectiveness of preoperative omega-3 FAs on postoperative inflammation markers (C-Reactive Protein [CRP], Interleukin-6 [IL-6], White Blood Count [WBC]) and hospital length of stay (LOS).
Conclusions:
- Preoperative administration of omega-3 FAs immunonutrients did not significantly impact the postoperative inflammatory response in patients undergoing abdominal surgery.
- The study's results are inconclusive, likely due to a limited number of trials and patients included.
- Further comprehensive studies are required to definitively determine the role of omega-3 FAs in this context.
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