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Updated: Jul 19, 2025

Investigating the Phagocytosis of Leishmania using Confocal Microscopy
Published on: July 29, 2021
Unfolded protein response pathway in leishmaniasis: A review
Nimesha Madhushani Edirisinghe1, Nuwani Harshamali Manamperi2, Vishmi Samudika Wanasinghe1
1Faculty of Medicine, Department of Parasitology, University of Colombo, Colombo, Sri Lanka.
None:
Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, Protein Kinase RNA-like ER kinase and Activating Transcription Factor 6 to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some pathogens can subvert the UPR to promote their survival and replication. Many intracellular pathogens, including Leishmania, can interact and hijack ER for their survival and replication, triggering ER stress and subsequently ER stress response. This review aims to provide a comprehensive overview of the ER stress response in infections with the Leishmania species.
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