Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

54
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
54
Gene Therapy00:59

Gene Therapy

25.5K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Letter to the Editor Regarding "Recovery of Parosmia Preferentially Influences Longitudinal Improvement of Quality of Life in C19OD".

International forum of allergy & rhinology·2026
Same author

Community-dwelling older adults' perspectives and experiences of living with multidimensional frailty and multimorbidity: a qualitative study.

Contemporary nurse·2026
Same author

Biosynthesis of active small molecule prenylsalidroside a and its anti-inflammatory activity.

Natural product research·2026
Same author

Evaluating the efficacy and readability of advanced large language models in responding to patients' frequently asked questions about chronic rhinosinusitis: a comparative analysis.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2026
Same author

[Research progress and industrialization prospect analysis of polysaccharides from traditional Chinese medicine with gelation properties].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2026
Same author

The miR-2110/<i>TRAF3</i> axis is associated with endothelial dysfunction and atherosclerosis in coronary heart disease.

Biochemistry and biophysics reports·2026

Related Experiment Video

Updated: Jul 19, 2025

Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification
04:43

Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification

Published on: October 11, 2024

2.0K

Bioorthogonal Engineered Virus-Like Nanoparticles for Efficient Gene Therapy.

Chun-Jie Bao1,2,3, Jia-Lun Duan1,2, Ying Xie1

  • 1State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Molecular Pharmaceutics and Drug Delivery Systems, and School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.

Nano-Micro Letters
|August 12, 2023
PubMed
Summary
This summary is machine-generated.

A novel virus-like nanoparticle, the bioorthogonal engineered virus-like recombinant biosome (reBiosome), enhances gene delivery for cancer and inflammatory diseases. This platform shows reduced immunogenicity and improved therapeutic efficacy.

Keywords:
Bioorthogonal chemistryGene therapyRecombinant biosomeSite-specific codon mutationVirus-like nanoparticle

More Related Videos

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
09:20

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants

Published on: October 18, 2022

4.6K
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
12:30

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

9.9K

Related Experiment Videos

Last Updated: Jul 19, 2025

Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification
04:43

Author Spotlight: Optimizing Digital Droplet PCR Method for Accurate Adeno-Associated Viral Genome Quantification

Published on: October 11, 2024

2.0K
Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
09:20

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants

Published on: October 18, 2022

4.6K
Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers
12:30

Vascular Gene Transfer from Metallic Stent Surfaces Using Adenoviral Vectors Tethered through Hydrolysable Cross-linkers

Published on: August 12, 2014

9.9K

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Gene Therapy

Background:

  • Gene therapy faces challenges in targeted tissue delivery.
  • Developing safe and effective gene delivery vectors is crucial for treating diseases.

Purpose of the Study:

  • To develop a novel virus-like nanoparticle, reBiosome, for efficient gene therapy.
  • To evaluate reBiosome's efficacy in treating cancer and inflammatory diseases.

Main Methods:

  • Engineered mutant virus-like biosomes (mBiosomes) displaying 4-azido-L-phenylalanine.
  • Bioorthogonal chemistry to attach weak acid-responsive polymers, creating reBiosomes.
  • In vivo studies in breast cancer and arthritis models.

Main Results:

  • reBiosome demonstrated reduced immunogenicity and prolonged blood circulation.
  • Enhanced gene delivery to weakly acidic tumor and arthritic tissues.
  • Robust therapeutic efficacy in preclinical cancer and arthritis models.

Conclusions:

  • reBiosome is a safe and efficient platform for gene therapies.
  • This nanoparticle technology holds promise for treating cancer and inflammatory diseases.
  • The study presents a universal platform for advanced gene delivery applications.