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The Cancer Moonshot Immuno-Oncology Translational Network at 5: accelerating cancer immunotherapies

Ananth Annapragada1, Andrew G Sikora2, Himangi Marathe3

  • 1Edward B. Singleton Department of Radiology, Texas Children's Hospital and Baylor College of Medicine, Houston, TX, USA.

Journal of the National Cancer Institute
|August 12, 2023
PubMed

Insights

The Immuno-Oncology Translational Network (IOTN) accelerates cancer immunology research translation. It identifies barriers and proposes solutions to improve immunotherapy outcomes for adult cancer patients.

Area of Science:

  • Cancer Immunology
  • Translational Research
  • Immunotherapy

Background:

  • Established in 2018, the Immuno-Oncology Translational Network (IOTN) supports the Cancer Moonshot initiative.
  • Recent national goals aim to halve cancer death rates and improve patient/survivor quality of life.
  • IOTN focuses on advancing cancer immunology research from laboratory discovery to clinical application.

Purpose of the Study:

  • To report on the progress and initiatives of the IOTN.
  • To highlight the development of resources for cancer immunology research.
  • To identify challenges and recommend actions for translating immuno-oncology concepts into clinical practice.

Main Methods:

  • Describing IOTN's unique structure and team science approach.
  • Summarizing research insights and their translational potential.
  • Analyzing barriers to clinical translation of immuno-oncology strategies.

Main Results:

  • IOTN has made progress in accelerating research translation and developing resources.
  • New insights from IOTN researchers show promise for several cancer types.
  • Barriers to clinical translation and areas for investment have been identified.

Conclusions:

  • The IOTN is advancing cancer immunology research and improving immunotherapy outcomes.
  • Addressing identified barriers requires novel funding mechanisms and resource development.
  • Strategic investments are crucial for high-yield advancements in immuno-oncology.

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