The risk factors for probable REM sleep behavior disorder: A case-control study.
Yaqin Xiang1, Xiaoxia Zhou1, XiuRong Huang1
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Sleep Medicine
|August 12, 2023
Summary
This study identified key risk factors for REM sleep behavior disorder (RBD), including alcohol consumption, depression, arthritis, constipation, and hyposmia. These findings highlight potential areas for early detection and intervention in RBD patients.
Area of Science:
- Neurology
- Sleep Medicine
- Epidemiology
Background:
- REM sleep behavior disorder (RBD) is a neurodegenerative disorder characterized by the loss of muscle atonia during REM sleep.
- Identifying risk factors for RBD is crucial for early diagnosis and intervention, potentially delaying or preventing associated neurodegenerative diseases like Parkinson's disease.
Purpose of the Study:
- To investigate potential risk factors associated with probable REM sleep behavior disorder (pRBD) using a case-control study design.
- To explore the relationship between demographic, lifestyle, comorbidity, prodromal symptoms, and blood biomarkers and the presence of pRBD.
Main Methods:
- A case-control study was conducted with 278 participants with probable RBD (pRBD) and 556 age- and sex-matched controls.
- Data collected included demographic information, lifestyle factors, comorbidities, prodromal symptoms of Parkinson's disease (PD), and blood biomarkers.
- Logistic regression and partial correlation analyses were used to assess associations between various factors and pRBD, and the severity of RBD with depression, respectively.
Main Results:
- Current alcohol consumption (OR 1.50), arthritis (OR 1.53), constipation (OR 1.93), hyposmia (OR 1.71), and depression (OR 3.15) were significantly associated with pRBD.
- Higher Hamilton Depression Rating Scale (HAMD-17) scores (OR 1.17) and borderline associations with total cholesterol and low-density lipoprotein were observed in the pRBD group.
- The severity of pRBD showed a positive correlation with depression (r=0.31, P<0.01).
Conclusions:
- Several risk factors, including lifestyle choices, comorbidities, and depressive symptoms, were identified for probable REM sleep behavior disorder (pRBD).
- The positive association between RBD severity and depression warrants further investigation.
- Further research is necessary to elucidate the underlying mechanisms connecting these identified factors to pRBD.
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